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Updated: Mar 9, 2026

Longitudinal Micro-Computed Tomography Image Analysis for User-Defined Region of Interest in Critical-Sized Bone Defects
Published on: June 24, 2025
A practical local tomography reconstruction algorithm based on a known sub-region
Pierre Paleo1, Michel Desvignes2, Alessandro Mirone1
1ESRF, 71 avenue des Martyrs, 38000 Grenoble, France.
Abstract:
A new method to reconstruct data acquired in a local tomography setup is proposed. This method uses an initial reconstruction and refines it by correcting the low-frequency artifacts, known as the cupping effect. A basis of Gaussian functions is used to correct the initial reconstruction. The coefficients of this basis are found by optimizing iteratively a fidelity term under the constraint of a known sub-region. Using a coarse basis reduces the degrees of freedom of the problem while actually correcting the cupping effect. Simulations show that the known region constraint yields an unbiased reconstruction, in accordance with uniqueness theorems stated in local tomography.
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