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Updated: Mar 9, 2026
A Murine Orthotopic Bladder Tumor Model and Tumor Detection System
Published on: January 12, 2017
Validation of a protein panel for the noninvasive detection of recurrent non-muscle invasive bladder cancer
Selma Gogalic1, Ursula Sauer1, Sara Doppler1
1a Health and Environment Department, Bioresources Unit, AIT Austrian Institute of Technology GmbH , Tulln , Austria.
Context:
About 50-70% of patients with non-muscle invasive bladder cancer (NMIBC) experience relapse of disease.
Objective:
To establish a panel of protein biomarkers incorporated in a multiplexed microarray (BCa chip) and a classifier for diagnosing recurrent NMIBC.
Materials And Methods:
Urine samples from 45 patients were tested. Diagnostic performance was evaluated by receiver operating characteristic (ROC) analysis.
Results:
A multi biomarker panel (ECadh, IL8, MMP9, EN2, VEGF, past recurrences, BCG therapies and stage at diagnosis) was identified yielding an area under the curve of 0.96.
Discussion And Conclusion:
This biomarker panel represents a potential diagnostic tool for noninvasive diagnosis of recurrent NMIBC.
