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Published on: February 3, 2014
Exercise testing for long-term follow-up in arrhythmogenic right ventricular cardiomyopathy
Daniel Karlsson1, Jan Engvall1, Agota Alfoldine Ando1
1Department of Clinical Physiology and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Objectives:
We investigated arrhythmia, electrocardiography and physical work capacity (PWC) in the follow-up of ARVC.
Design:
Twenty-three patients (13 men; age 41±12years) fulfilling diagnostic criteria were re-investigated after at least five years.
Results:
Ventricular arrhythmia during exercise testing (ET) was present in 14 patients (61%) and showed variation between examinations. In eleven (48%), complex ventricular ectopic activity was observed at peak exercise or immediately thereafter. Mutations known to be pathogenic in ARVC were present in 13 patients (57%) of which 11 developed complex ventricular arrhythmia at ET. PWC at baseline was 190±66W (104±26%) decreasing to 151±61W (91±23%, p=0.008) after 10.7years.
Conclusion:
The appearance of ventricular arrhythmia during exercise testing showed temporal variation but was frequent in patients with relevant genetic mutation. Physical exercise capacity decreased over time in patients with ARVC in excess to the age-related deterioration and regardless of medication.
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Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
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