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Terminology binding with SNOMED CT to bridge differences in information structures: a feasibility study
Anna Rossander1,2, David Wetterbro3, Daniel Karlsson4
1Karolinska Institutet, Stockholm, Sweden. anna.rossander@ki.se.
Journal of Biomedical Semantics
|July 24, 2026
Summary
Terminology binding to SNOMED CT showed low transformability between different healthcare information structures. Improving terminology binding guidelines and ontology definitions is key for better data interoperability.
Area of Science:
- Health Informatics
- Medical Terminology
- Data Interoperability
Background:
- Sharing healthcare information is crucial for patient well-being.
- Transforming between different data structures is often necessary for information exchange.
- Automating data transformation requires sufficiently structured information.
Purpose of the Study:
- To investigate if terminology binding to SNOMED CT can serve as a bridge between disparate information structures.
- To assess the transformability of semantically equivalent terms bound to SNOMED CT concepts.
Main Methods:
- A mixed-methods approach was used with two breast cancer pathology information structures.
- Clinicians and informaticians identified and verified semantically equivalent user interface terms.
- SNOMED CT concept pairs were categorized as transformable, partially transformable, or non-transformable.
Main Results:
- 70% of user interface terms mapped to the same SNOMED CT concept.
- Only 9% of term pairs bound to different SNOMED CT concepts were fully transformable.
- Obstacles included primitive concepts, sibling concepts, divergent binding strategies, and translation issues.
Conclusions:
- While SNOMED CT concept concordance was high (70%), transformability between different concepts was low (9%).
- Improving transformability requires better terminology-binding guidelines and enhanced SNOMED CT ontology definitions.
- Findings offer insights for enhancing healthcare data interoperability and terminology quality.

