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Endogenous Opiates and Behavior: 2015.

Richard J Bodnar1

  • 1Department of Psychology and Neuropsychology Doctoral Sub-Program, Queens College, City University of New York, Flushing, NY 11367, United States.

Peptides
|December 26, 2016
PubMed
Summary

This review covers 2015 research on the endogenous opioid system, detailing how manipulating opioid peptides and receptors affects behavior. It explores roles in pain, stress, addiction, and more.

Keywords:
Beta-endorphinDelta opioid receptorEndomorphinsEnkephalinsKappa opioid receptorMorphineMu opioid receptorNaloxoneNociceptionORL-1 receptor

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • The endogenous opioid system plays a crucial role in regulating various physiological and behavioral processes.
  • Annual reviews are essential for synthesizing the rapidly evolving research in this field.

Purpose of the Study:

  • To summarize research published in 2015 on the behavioral effects of manipulating the endogenous opioid system.
  • To provide an overview of studies investigating opioid peptides, receptors, agonists, and antagonists.

Main Methods:

  • Literature review of studies published in 2015.
  • Analysis of research on molecular, pharmacological, and genetic manipulations of the opioid system.
  • Synthesis of findings related to behavioral outcomes.

Main Results:

  • Behavioral effects were observed following molecular, pharmacological, and genetic manipulation of opioid peptides and receptors.
  • Opioid system modulation impacts a wide range of functions including pain, stress, addiction, learning, and mood.
  • Research explored neurochemical localization and molecular-biochemical effects of endogenous opioids.

Conclusions:

  • The endogenous opioid system is a complex modulator of diverse behaviors and physiological functions.
  • Continued research is vital for understanding the intricate roles of opioid peptides and receptors.
  • This review highlights the significant impact of opioid system research on various scientific disciplines.