Diltiazem attenuates the inotropic and peripheral vascular effects of cardiac glycosides

The influence of diltiazem on the hemodynamic effects of ouabain in 10 preinstrumented awake dogs was studied. Mean aortic pressure increased from 102 to 119 mm Hg with ouabain (p less than 0.05), an effect that was attenuated by pretreatment with diltiazem. The increase in systemic vascular resistance of 30% with ouabain was ablated by prior diltiazem. Heart rate did not significantly change with ouabain or with diltiazem plus ouabain, but intravenous diltiazem alone produced a reflex increase in heart rate of 26%. Left ventricular (LV) end-diastolic dimension was significantly greater with ouabain alone, but not with ouabain after pretreatment with diltiazem. LV dP/dt max increased by 40% with ouabain alone, but by only 23% (p less than 0.001) after pretreatment with diltiazem plus ouabain. When observed at matched preload and heart rate, diltiazem markedly attenuates the positive inotropic and peripheral arterial constrictive effects of acute ouabain administration in the conscious animal with normal LV function.