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Pertussis in neonates.

C D Christie1, R S Baltimore

  • 1Department of Pediatrics, Yale University School of Medicine, New Haven, Conn.

American Journal of Diseases of Children (1960)
|October 1, 1989
PubMed
Summary
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Maternal-neonatal pertussis is rare but serious. Adolescent mothers can transmit pertussis (whooping cough) to newborns, leading to severe illness and missed diagnoses.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Neonatology

Background:

  • Pertussis (whooping cough) is a highly contagious respiratory infection.
  • While pertussis is increasing in adolescents and infants, maternal-neonatal transmission is infrequently reported.
  • Early diagnosis and intervention are crucial for managing pertussis in vulnerable populations.

Observation:

  • This study details three neonates who contracted pertussis from their adolescent mothers.
  • Mothers presented with mild respiratory symptoms, leading to delayed diagnosis in neonates.
  • Newborns exhibited severe coughing, choking, apnea, and cyanosis, mimicking other conditions.

Findings:

  • All three neonates had pertussis initially missed by clinicians.
  • Two neonates experienced apnea, bradycardia, and unresponsiveness, with a clinical course resembling the "100-day cough".

Related Experiment Videos

  • One neonate developed a fatal pulmonary hemorrhage; the other two required extensive ventilatory support and hospitalization.
  • Implications:

    • Highlights the risk of severe pertussis in neonates born to mothers with mild or undiagnosed infections.
    • Emphasizes the need for heightened clinical suspicion for pertussis in neonates presenting with severe respiratory distress.
    • Underscores the importance of maternal vaccination and improved diagnostic strategies to prevent neonatal pertussis mortality and morbidity.