Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Vaccinations

Vaccinations

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure...

Principles of Disease Surveillance

Principles of Disease Surveillance

Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...

Decision Making: Traditional Method

Decision Making: Traditional Method

The process of hypothesis testing based on the traditional method includes calculating the critical value, testing the value of the test statistic using the sample data, and interpreting these values.
First, a specific claim about the population parameter is decided based on the research question and is stated in a simple form. Further, an opposing statement to this claim is also stated. These statements can act as null and alternative hypotheses, out of which a null hypothesis would be a...

Methods Of Healthcare Delivery System

Methods Of Healthcare Delivery System

At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Systems Thinking Tools to Shift Stakeholder Engagement in Food and Nutrition Insecurity.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2026

Same author

Exploring Contextual Influences on the Implementation and Impact of Safe Streets, a Community Violence Intervention.

Journal of urban health : bulletin of the New York Academy of Medicine·2025

Same author

Adherence to the combined Mediterranean-dietary approaches to stop hypertension diet is shaped by neighborhood socio-economics and food environments.

Health & place·2025

Same author

Toward Health Equity: A Workshop Report on the State of the Science of Obesity Interventions for Adults.

Obesity (Silver Spring, Md.)·2025

Same author

How Systems Mapping Can Be an Important Health Communication Tool.

Journal of health communication·2025

Same author

Computationally Modeling the Physiologic Impact of the Ratio of Fats to Carbohydrates in the Diet on Intake Among Metabolically Healthy Adults.

Current developments in nutrition·2025

Search research articles

Related Experiment Video

Updated: Mar 9, 2026

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

A systems approach to vaccine decision making.

Bruce Y Lee¹, Leslie E Mueller¹, Carla G Tilchin¹

¹Public Health Computational and Operations Research (PHICOR), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

|December 27, 2016

Summary

Adopting a systems approach, using computational modeling, is crucial for effective vaccine decision-making. This method helps uncover complex interdependencies and avoid unintended consequences for better public health outcomes.

Keywords:

Computational modeling Decision making Systems Vaccines

More Related Videos

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Published on: May 6, 2015

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

Related Experiment Videos

Last Updated: Mar 9, 2026

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Published on: May 6, 2015

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

Area of Science:

Public Health
Computational Biology
Health Systems Research

Background:

Vaccine decision-making involves complex biological, social, and operational factors.
Ignoring these systemic relationships can lead to ineffective or unsustainable interventions.

Purpose of the Study:

To highlight the importance of a systems approach in vaccine decision-making.
To present lessons learned from using computational models to integrate systems thinking into vaccine strategies.

Main Methods:

Utilized mathematical and computational modeling as "virtual laboratories" to analyze complex vaccine systems.
Examined the interplay of various components including biological, clinical, behavioral, social, operational, environmental, and economic factors.

Main Results:

Identified ten key lessons learned from applying computational models to vaccine decision-making.
Demonstrated that traditional single-measure approaches can overlook crucial system dynamics and indirect effects.
Highlighted the dynamic nature of vaccine value and the importance of considering the entire vaccine ecosystem.

Conclusions:

A comprehensive systems approach, facilitated by computational modeling, is essential for optimizing vaccine strategies.
Effective vaccine policy requires understanding multifaceted interactions and potential unintended consequences.
This approach enhances the efficiency and sustainability of vaccine programs and maximizes their broader impact.