[Development of osteoporosis drugs -the past, the present and the future-.]

From 1990s to 2000s, new drugs for osteoporosis have been developed, and the bone metabolism researches have livened up. In those days, many a people gathered to the meeting from many countries, and the each booth of pharmaceutics was proud of its preeminence. The dedications by the society and its members have had osteoporosis diagnostics developed, the anchor drugs become prevalent, and the number of fractures reduced. Although the brilliant effects of Romosozumab and Abaloparatide were presented in the meeting held this year, the members had to accept the convergence state of new drug developments. But some problems have been still left unsolved, the development of more effective drugs to prevent fragile bone fractures without any adverse events, the safety of long term use of the osteoporosis drugs, and the effectiveness of drugs to prevent from fractures of the oldest old people.