Related Experiment Video
Updated: Mar 9, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Survey Evaluating the Practice of Children's Hospitals Having Pharmacist Collaborative Drug Therapy Management
Chelsea Welsh1, Rukshana Miah1, Jennifer Girotto2
1University of Connecticut, Storrs, Connecticut.
Insights
Pharmacist-physician collaborative drug therapy management (CDTM) is used in about one-third of US children's hospitals. Pharmacists commonly initiate, monitor, and adjust therapies, particularly for vancomycin and aminoglycosides.
Area of Science:
- Pediatric Pharmacy Practice
- Pharmacoeconomics
- Health Services Research
Background:
- Collaborative Drug Therapy Management (CDTM) enhances patient care through pharmacist-physician partnerships.
- Understanding the adoption of CDTM in pediatric settings is crucial for optimizing medication management.
- Limited data exists on the prevalence and specific applications of CDTM in children's hospitals.
Purpose of the Study:
- To determine the frequency of pharmacist-physician CDTM use in US children's hospitals.
- To characterize the scope and nature of CDTM implementation in these institutions.
Main Methods:
- A national phone survey was conducted targeting children's hospitals in the US.
- Data collection occurred between February and April 2014.
- Surveys gathered information on hospital demographics, CDTM utilization, and specific medications managed under CDTM.
Main Results:
- Of 171 identified children's hospitals, 88 (51.5%) completed the survey.
- 32 (31.7%) reported having some level of CDTM in place.
- Pharmacists commonly initiated, monitored, and modified drug therapy, with vancomycin and aminoglycosides being the most frequent medications included in protocols.
Conclusions:
- CDTM is implemented in approximately one-third of children's hospitals nationwide.
- Pharmacists play an active role in CDTM, managing dosing and therapy.
- Lack of medical staff support was identified as a primary barrier to CDTM adoption.
Abstract:
OBJECTIVES: The purpose of this study is to determine how frequently children's hospitals in the United States are using pharmacist-physician collaborative drug therapy management (CDTM), and to characterize their use in this population. METHODS: A phone survey was created to collect data regarding the use of pharmacist-physician CDTM at children's hospitals. Children's hospitals were called between February 2014 and April 2014. Data were collected from either a clinical pharmacist or pharmacy director. Pharmacists were asked to answer questions regarding hospital demographics as well as to what extent and for which medications they use CDTM. Differences between types of hospitals were evaluated using Fisher exact test. RESULTS: A total of 171 children's hospitals were identified; 51.5% hospitals (n = 88) completed the survey. Of the 88 hospitals that completed the survey, 32 (31.7%) had some level of CDTM in place. Of the 28 children's hospitals with CDTM in place that completed the survey, all allowed pharmacists to modify doses and monitor therapy, and 75% provided pharmacists with the ability to initiate the first dose. The specific medications that were included in the CDTM protocols in children's hospitals included vancomycin (n = 23), aminoglycosides (n = 22), anticoagulation medications (n = 7), and total parenteral nutrition (n = 3). Training was required for pharmacists to participate in CDTM protocols at most hospitals (n = 26). Lack of support from medical staff was the most common perceived barrier. No differences were identified between types of children's hospitals. CONCLUSION: CDTM protocols are practiced in about one third of the children's hospitals. Pharmacists commonly initiate, monitor, and modify therapies as part of these protocols. The most frequently included medications were vancomycin and aminoglycosides.
Related Concept Videos
Pharmacokinetics in Pediatric Patients: Drug Excretion
Pharmacokinetics in Pediatric Patients: Drug Distribution
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Drug Dosing: Infants and Children
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Dosage Regimens: Designs and Approaches

