Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Computed Tomography01:10

Computed Tomography

9.2K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
9.2K
Doppler Effect - II01:05

Doppler Effect - II

5.0K
The Doppler effect has several practical, real-world applications. For instance, meteorologists use Doppler radars to interpret weather events based on the Doppler effect. Typically, a transmitter emits radio waves at a specific frequency toward the sky from a weather station. The radio waves bounce off the clouds and precipitation and travel back to the weather station. The radio frequency of the waves reflected back to the station appears to decrease if the clouds or precipitation are moving...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A functional amyloid matrix underpins the PDIM-architected corded superstructure of the <i>Mycobacterium tuberculosis</i> biofilm.

bioRxiv : the preprint server for biology·2026
Same author

Retinal OCT Parameters and Physiological Dynamics as an Effect of Anesthesia in C57BL/6J Mice.

Investigative ophthalmology & visual science·2026
Same author

Evolving landscape of glioblastoma research : A 75-year bibliometric study on survival, treatment and gender in authorship.

Wiener klinische Wochenschrift·2026
Same author

Blood flow analysis of retinal neovascularisations in a VLDLR mouse model using contrast-enhanced optical coherence tomography.

Biomedical optics express·2026
Same author

Ultrasensitive Saliva-Based Detection of Early Alzheimer's Disease Biomarkers via Nanoparticle-Enhanced Evanescent Scattering Microscopy.

ACS sensors·2026
Same author

Optical coherence photoacoustic microscopy for 3D cancer model imaging with AI-assisted organoid analysis.

Light, science & applications·2026
Same journal

Generalizable framework for multi-site bone density prediction using non-dominant wrist optical biomarkers.

Biomedical optics express·2026
Same journal

Erratum: Review of dynamic optical coherence tomography for intracellular motility [Invited]: errata.

Biomedical optics express·2026
Same journal

Digital-micromirror-device-based illumination strategies for background suppression in single-molecule localization microscopy.

Biomedical optics express·2026
Same journal

Synergistic combination of convective self-assembly and hollow core fiber for sensitive SERS detection of glucose molecules.

Biomedical optics express·2026
Same journal

Multimodal diagnostic network integrating infrared and mass spectra for lung cancer.

Biomedical optics express·2026
Same journal

Multimodal Optical Biosensing for Precision Medicine and Healthcare: Introduction to the feature issue.

Biomedical optics express·2026
See all related articles

Related Experiment Video

Updated: Mar 9, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

19.3K

Active-passive path-length encoded (APPLE) Doppler OCT.

Andreas Wartak1, Richard Haindl1, Wolfgang Trasischker1

  • 1Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Währinger Gürtel 18-20 / 4L, 1090 Vienna, Austria.

Biomedical Optics Express
|December 27, 2016
PubMed
Summary
This summary is machine-generated.

This study introduces a new method for 3D blood flow measurement in the eye. The active-passive path-length encoded Doppler optical coherence tomography (APPLE DOCT) system enables non-invasive imaging for diagnosing ocular diseases.

Keywords:
(110.4500) Optical coherence tomography(170.0170) Medical optics and biotechnology(170.2655) Functional monitoring and imaging(170.3340) Laser Doppler velocimetry(170.4470) Ophthalmology

More Related Videos

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
11:21

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Published on: January 15, 2013

12.0K
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

3.6K

Related Experiment Videos

Last Updated: Mar 9, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

19.3K
Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
11:21

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Published on: January 15, 2013

12.0K
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

3.6K

Area of Science:

  • Biomedical Optics
  • Ophthalmology
  • Medical Imaging

Background:

  • Accurate measurement of ocular blood flow is crucial for diagnosing and monitoring major eye diseases.
  • Current methods for blood flow quantification may have limitations in resolution or invasiveness.

Purpose of the Study:

  • To develop and validate a novel active-passive path-length encoded (APPLE) swept source Doppler optical coherence tomography (DOCT) system.
  • To enable non-invasive, three-dimensional velocity vector reconstruction of moving particles for ocular blood flow investigations.

Main Methods:

  • Implementation of an APPLE swept source DOCT system.
  • Demonstration of system performance using an in vitro flow phantom.
  • In vivo validation through retinal vessel bifurcation measurements in healthy human volunteers.

Main Results:

  • Successful three-dimensional velocity vector reconstruction of moving particles without prior knowledge of motion orientation.
  • Demonstrated non-invasive in vivo blood flow measurements.
  • Quantified total retinal blood flow in healthy subjects.

Conclusions:

  • The developed APPLE DOCT system provides a novel approach for quantitative human ocular blood flow measurements.
  • This technology has the potential to aid in the diagnosis and monitoring of significant ocular diseases.
  • Further research can explore its application in various pathological conditions affecting retinal vasculature.