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Hypercoagulability in arterial disease.

C R Spillert1, V J Milazzo, W D Suval

  • 1Department of Surgery, UMDNJ/New Jersey Medical School, Newark.

Angiology
|October 1, 1989
PubMed
Summary
This summary is machine-generated.

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Patients with peripheral arterial occlusive disease exhibit a hypercoagulable state, indicated by shortened blood recalcification times after endotoxin stimulation. This finding suggests implications for diagnosis and treatment of vascular disease.

Area of Science:

  • Hematology
  • Vascular Biology
  • Immunology

Background:

  • Monocytes are key immune cells that can activate the clotting system.
  • Tissue factor generation by monocytes serves as a marker for monocyte activation and coagulation.
  • Peripheral arterial occlusive disease (PAOD) is associated with circulatory complications.

Purpose of the Study:

  • To investigate the presence of a hypercoagulable state in patients with PAOD.
  • To compare blood coagulability in PAOD patients versus healthy volunteers using an endotoxin-stimulated clotting assay.

Main Methods:

  • Isolated human monocytes were stimulated with endotoxin.
  • Blood recalcification time was determined after incubation with endotoxin and addition of CaCl2.
  • The assay was used to assess hypercoagulability in 31 PAOD patients and 19 healthy volunteers.

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Main Results:

  • Endotoxin stimulation significantly shortened the recalcification time in both healthy volunteers and PAOD patients.
  • PAOD patients exhibited significantly shorter recalcification times compared to healthy volunteers, indicating a hypercoagulable state (p < .001).
  • The mean recalcification time for endotoxin-activated blood was shorter in PAOD patients (4.55 +/- 0.9 min) than in healthy volunteers (5.69 +/- 0.7 min).

Conclusions:

  • Patients with peripheral arterial occlusive disease possess an underlying hypercoagulable state.
  • This hypercoagulability may exacerbate the arterial occlusive process in PAOD.
  • The findings suggest potential diagnostic, therapeutic, and prognostic significance for this hypercoagulable state in vascular disease management.