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Whole blood platelet aggregation in uremic dogs
L T Forsythe1, M L Jackson, S M Meric
1Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon.
American Journal of Veterinary Research
|October 1, 1989
Summary
Platelet aggregation in uremic dogs did not differ significantly from healthy controls when measured using whole blood aggregometry. This suggests that common platelet function tests may not detect bleeding risks in dogs with kidney disease.
Area of Science:
- Veterinary Medicine
- Hematology
- Nephrology
Background:
- Uremia, a condition associated with renal disease, can affect various physiological processes.
- Platelet dysfunction is a potential complication of uremia, impacting hemostasis.
- Assessing platelet function is crucial for identifying bleeding risks in affected animals.
Purpose of the Study:
- To evaluate whole blood platelet aggregation responses in dogs with renal disease.
- To compare platelet function between uremic and healthy control dogs.
- To determine if whole blood aggregometry can detect platelet defects in uremic dogs.
Main Methods:
- Whole blood platelet aggregation was measured using the impedance method.
- Responses to collagen, arachidonic acid, and adenosine diphosphate were assessed.
- Uremic dogs (serum urea ≥ 20 mmol/L) were compared to healthy controls.
Main Results:
- No significant differences in platelet aggregation were observed between uremic and control dogs for any agonist.
- Median impedance changes for collagen, arachidonic acid, and adenosine diphosphate were similar in both groups.
- Hemorrhagic tendencies were not detected in uremic dogs via whole blood platelet aggregation.
Conclusions:
- Whole blood platelet aggregometry does not appear to be abnormal in uremic dogs.
- This method may not detect all potential platelet aggregation defects in dogs with renal disease.
- Further investigation into platelet function in uremic dogs may be warranted.