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Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
Published on: September 20, 2024
841
Variability in neural excitability and plasticity induction in the human cortex: A brain stimulation study
Brenton Hordacre1, Mitchell R Goldsworthy2, Ann-Maree Vallence3
1The Robinson Research Institute, School of Medicine, The University of Adelaide, Adelaide 5005, Australia.
Brain Stimulation
|December 28, 2016
Summary
Understanding non-invasive brain stimulation (NIBS) variability is key. Baseline motor evoked potential (MEP) variability and late I-wave recruitment predict continuous theta burst stimulation (cTBS) response, improving NIBS reliability.
Area of Science:
- Neuroscience
- Neurophysiology
- Brain Stimulation
Background:
- Non-invasive brain stimulation (NIBS) shows potential for studying and inducing neuroplasticity.
- High response variability currently limits the utility of NIBS.
- Cortical excitability, particularly late I-wave circuits, influences NIBS outcomes.
Purpose of the Study:
- To investigate if motor evoked potential (MEP) amplitude variability predicts response variability in continuous theta burst stimulation (cTBS).
- To determine the association between I-wave recruitment and MEP variability in NIBS response.
Main Methods:
- Thirty-four healthy participants underwent two experiments.
- Experiment 1 assessed baseline MEP variability and cTBS response.
- Experiment 2 examined the relationship between I-wave recruitment and MEP variability.
Main Results:
- Both baseline MEP variability and late I-wave recruitment correlate with cTBS response.
- These two factors are independent predictors.
- Together, they explain 31% of the variability in cTBS response.
Conclusions:
- This research clarifies physiological mechanisms behind NIBS plasticity.
- Findings may lead to more predictable and reliable NIBS protocols.
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