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Related Concept Videos

Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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Necrosis01:16

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
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Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Related Experiment Video

Updated: May 5, 2026

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies
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Extensive bone marrow necrosis in cancer.

R Suri1, Y O Tan

  • 1Department of Medicine, National University of Singapore.

Annals of the Academy of Medicine, Singapore
|July 1, 1989
PubMed
Summary

Extensive bone marrow necrosis, a rare cancer complication, can be the initial sign of disease. Early detection and management of this condition may lead to remission and marrow regeneration.

Area of Science:

  • Hematology
  • Oncology

Background:

  • Extensive bone marrow necrosis is an uncommon complication in cancer patients.
  • It can present as the initial clinical manifestation of malignancy.

Observation:

  • This paper details two cases where extensive bone marrow necrosis was the presenting feature.
  • The clinical presentation, diagnostic challenges, and management strategies were analyzed.

Findings:

  • The diagnostic criteria for bone marrow necrosis in cancer patients are discussed.
  • The pathogenesis and prognosis of this condition remain poorly understood.
  • While prognosis is typically poor, prompt recognition is crucial.

Implications:

  • Early diagnosis and appropriate management of bone marrow necrosis can lead to disease remission.

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  • Regeneration of bone marrow is possible with timely intervention.
  • This highlights the importance of considering bone marrow necrosis in cancer patients with unexplained symptoms.