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Hypertrophic cardiomyopathy with aortic dilation: a novel observation

Rayan Yousefzai1, Anushree Agarwal1, M Fuad Jan1

  • 1Aurora Cardiovascular Services, Aurora Sinai/Aurora St. Luke's Medical Centers, University of Wisconsin School of Medicine and Public Health, 2801 W. Kinnickinnic River Parkway, Ste. 840, Milwaukee, WI, USA.

European Heart Journal. Cardiovascular Imaging
|December 28, 2016
PubMed

Insights

This study found that 9.0% of patients with hypertrophic cardiomyopathy (HCM) also have aortic dilation. This highlights a potential link between these two cardiovascular conditions that warrants further investigation.

Area of Science:

  • Cardiology
  • Genetics
  • Vascular Medicine

Background:

  • Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease.
  • Aortic dilation is a condition that can run in families.
  • Data on the prevalence of aortic dilation in HCM patients is limited.

Purpose of the Study:

  • To determine the prevalence of aortic dilation in patients diagnosed with hypertrophic cardiomyopathy.
  • To investigate the association between aortic dilation and HCM.

Main Methods:

  • Observational retrospective study.
  • Included 201 patients referred to an HCM center between January 2011 and March 2014.
  • Aortic dilation defined using American Society of Echocardiography and European Association of Cardiovascular Imaging guidelines.

Main Results:

  • 18 out of 201 (9.0%) HCM patients met the criteria for aortic dilation.
  • Patients with aortic dilation were more likely to be male, less likely to be hypertensive, and had larger left ventricle diameter and more aortic valve regurgitation.
  • Mean ascending aorta diameter was 4.0 cm in males and 3.8 cm in females; mean sinuses of Valsalva diameter was 4.2 cm in males and 3.8 cm in females.

Conclusions:

  • A novel observation of 9.0% prevalence of aortic dilation in HCM patients is reported.
  • Further research is needed to understand the genetic and pathophysiological basis of this association.
  • Clinical implications of aortic dilation in HCM patients require further study in larger cohorts.
Abstract

Keywords:
aortageneticshypertrophic cardiomyopathy

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