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Versatile Flexible Graphene Multielectrode Arrays.

Dmitry Kireev¹, Silke Seyock², Mathis Ernst³

¹Institute of Bioelectronics (PGI-8/ICS-8), Forschungszentrum Jülich, 52425 Jülich, Germany. d.kireev@fz-juelich.de.

|December 28, 2016

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This summary is machine-generated.

Graphene microelectrodes demonstrate excellent performance for bioelectronic applications. These flexible sensors show high signal-to-noise ratios for recording electrical activity in heart tissue and cells.

Area of Science:

Materials Science
Bioelectronics
Biomedical Engineering

Background:

Graphene possesses unique properties making it suitable for advanced bioelectronic devices.
Flexible substrates are crucial for developing implantable or wearable biosensors.
Graphene microelectrodes (GMEAs) offer potential for high-resolution biological signal detection.

Purpose of the Study:

To evaluate the performance of graphene microelectrodes (GMEAs) fabricated on a flexible polyimide substrate.
To assess the biocompatibility and suitability of GMEAs for extracellular recordings of biological electrical activity.
To determine the signal-to-noise ratio (SNR) achieved by GMEAs in biological samples.

Main Methods:

Fabrication of dense arrays of graphene microelectrodes on a flexible polyimide substrate.

Keywords:

GMEA cell-graphene interface extracellular recordings graphene graphene electrodes

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Electrical impedance spectroscopy was used to characterize GMEA performance.

Extracellular recordings of electrical activities were performed on acute heart tissue and cardiac muscle cells (HL-1).

Main Results:

GMEAs demonstrated encouraging signal-to-noise ratios: 65 ± 15 for heart tissue and 20 ± 10 for HL-1 cells.
Electrical impedance spectroscopy confirmed the functional performance of the GMEAs.
The devices exhibited low noise and excellent robustness.

Conclusions:

Graphene microelectrodes are a promising technology for bioelectronic applications.
The tested GMEAs are suitable for diverse, biologically relevant applications requiring sensitive electrical recordings.
The combination of flexibility, low noise, and robustness makes GMEAs ideal for extracellular recordings.