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Biocompatibility of large-area two-dimensional electronic materials with neural stem cells
R Taranath Jayanth1,2,3, Rebecca Duquette4,2, Shanmukh Kutagulla1,5
1Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, TX 78758, USA.
Cell Reports. Physical Science
|March 23, 2026
Summary
Large-area 2D electronic materials support neural stem cell viability and differentiation. Material format influences neuronal maturation and glial lineage commitment, offering tunable platforms for neural interfaces.
Area of Science:
- Materials Science
- Neuroscience
- Biotechnology
Background:
- Two-dimensional (2D) electronic materials show promise for flexible neural interfaces.
- Biocompatibility of large-area 2D materials is not well understood, as most studies use exfoliated flakes or suspensions.
Purpose of the Study:
- To systematically compare the in vitro biocompatibility of various large-area 2D electronic materials.
- To evaluate their potential as substrates for neural stem cells and neuronal differentiation.
Main Methods:
- Comparison of chemical-vapor-deposited graphene, MoS2, PtSe2, and PtTe2, alongside flaky MoS2 and thin-film metals.
- Assessment of mouse neural stem cell viability, metabolic activity, and neuronal differentiation on these substrates.
Main Results:
- All large-area 2D materials supported neural stem cell viability and differentiation, comparable to laminin-coated glass.
- Flaky MoS2 enhanced neuronal maturation, while PtSe2 promoted glial lineage differentiation.
Conclusions:
- Large-area 2D materials are biocompatible and tunable platforms for neural interfacing.
- Material format is a critical factor in designing bioelectronic devices for neural applications.
