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In vitro activities of lomefloxacin and temafloxacin against pathogens causing diarrhea
J Segreti1, J A Nelson, L J Goodman
1Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.
Abstract:
The in vitro activities of temafloxacin (A63004) and lomefloxacin (SC-47111; NY-198) were compared with those of seven other antibiotics against 146 isolates of bacterial enteric pathogens, including Campylobacter jejuni and Campylobacter coli. Ciprofloxacin was the most active drug against the Salmonella, Shigella, Yersinia, and Vibrio spp. tested. Lomefloxacin, temafloxacin, and difloxacin were the most active drugs tested against Campylobacter spp. (MIC for 90% of strains, 0.125 to 0.25 micrograms/ml).
Insights
Temafloxacin and lomefloxacin showed strong in vitro activity against Campylobacter species, a common bacterial enteric pathogen. Ciprofloxacin was most effective against Salmonella, Shigella, Yersinia, and Vibrio species.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Bacterial enteric pathogens cause significant gastrointestinal infections worldwide.
- Fluoroquinolones are a class of antibiotics used to treat bacterial infections.
- Understanding the in vitro activity of antibiotics is crucial for guiding clinical treatment decisions.
Purpose of the Study:
- To compare the in vitro antibacterial activity of temafloxacin and lomefloxacin against key bacterial enteric pathogens.
- To evaluate the efficacy of these fluoroquinolones against Campylobacter jejuni and Campylobacter coli.
Main Methods:
- In vitro susceptibility testing was performed on 146 isolates of bacterial enteric pathogens.
- Minimum Inhibitory Concentrations (MICs) were determined for temafloxacin, lomefloxacin, and seven other antibiotics.
- The study included isolates of Salmonella, Shigella, Yersinia, Vibrio, Campylobacter jejuni, and Campylobacter coli.
Main Results:
- Ciprofloxacin exhibited the highest activity against Salmonella, Shigella, Yersinia, and Vibrio species.
- Temafloxacin, lomefloxacin, and difloxacin demonstrated potent activity against Campylobacter species.
- The MIC for 90% of Campylobacter strains ranged from 0.125 to 0.25 µg/ml for these three drugs.
Conclusions:
- Temafloxacin and lomefloxacin are highly effective in vitro against Campylobacter species.
- Ciprofloxacin remains a potent agent against other common enteric bacterial pathogens.
- These findings support the potential utility of temafloxacin and lomefloxacin in treating Campylobacter infections.