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Allergic Reactions: Anaphylaxis

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...

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Zebrafish Animal Model for the Study of Allergic Reactions in Response to Tick Saliva Biomolecules

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Shellfish allergens: tropomyosin and beyond.

M A Faber¹, M Pascal², O El Kharbouchi¹

¹Department of Immunology - Allergology - Rheumatology, Faculty of Medicine and Health Science, University of Antwerp and Antwerp University Hospital, Wilrijk, Belgium.

|December 28, 2016

Summary

This summary is machine-generated.

Shellfish allergy, particularly from crustaceans like shrimp, is a significant health concern. This review details key allergens, including tropomyosin and hemocyanin, involved in these reactions.

Keywords:

Allergens cross-reactivity crustaceans mollusks shrimp

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Area of Science:

Food allergy research
Immunology
Crustacean biology

Background:

IgE-mediated shellfish allergy is a common cause of adverse food reactions.
Shellfish include mollusks and crustaceans; crustaceans, especially shrimp, are frequent allergens.
Several major and minor shellfish allergens have been identified.

Purpose of the Study:

To review current knowledge on major shellfish allergens.
To focus on allergens found in crustaceans, particularly shrimp.
To summarize identified and cloned allergens.

Main Methods:

Literature review of scientific studies on shellfish allergy.
Analysis of identified and cloned shellfish allergens.
Focus on invertebrate tropomyosin, arginine kinase, myosin light chain, sarcoplasmic calcium-binding protein, and hemocyanin.

Main Results:

Invertebrate tropomyosin is a predominant allergen in shrimp allergy.
Arginine kinase, myosin light chain, sarcoplasmic calcium-binding protein, and hemocyanin are also relevant crustacean allergens.
These allergens play a key role in IgE-mediated reactions.

Conclusions:

Understanding these specific allergens is crucial for diagnosing and managing shellfish allergy.
Further research into crustacean allergens can improve clinical outcomes.
Tropomyosin and other identified proteins are central to crustacean hypersensitivity.