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Contrast enhanced renal MR angiography at 7 Tesla: How much gadolinium do we need?

Karsten Beiderwellen1, Oliver Kraff2, Anja Laader1

  • 1Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany; Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany.

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Summary

A reduced dose of Gadobutrol (0.025mmol/kg BW) is effective for renal magnetic resonance angiography (MRA) at 7 Tesla, maintaining diagnostic image quality. This finding is crucial for patients with kidney issues.

Keywords:
AngiographyContrast mediaGadoliniumMagnetic resonance imagingRenal artery

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Area of Science:

  • Radiology
  • Medical Imaging
  • Magnetic Resonance Imaging

Background:

  • Renal magnetic resonance angiography (MRA) is vital for diagnosing kidney conditions.
  • Gadobutrol is a common contrast agent used in MRA.
  • Optimizing contrast agent dosage is important for safety and cost-effectiveness, especially in patients with renal impairment.

Purpose of the Study:

  • To evaluate the feasibility of reducing Gadobutrol dosage for 7 Tesla (T) renal MRA.
  • To determine if diagnostic image quality can be preserved with lower Gadobutrol doses.

Main Methods:

  • Ten healthy volunteers underwent renal MRA using a 7T scanner.
  • Data acquisition involved Fast Low Angle Shot (FLASH) sequences with three Gadobutrol doses (0.1, 0.05, 0.025 mmol/kg BW).
  • Contrast ratios (CR) and qualitative vessel delineation were assessed.

Main Results:

  • All tested Gadobutrol doses provided good visualization of the aorta and renal arteries.
  • Higher contrast ratios were observed for full and half doses compared to the quarter dose in segmental arteries.
  • No significant difference in image quality was found between full and half doses, but the quarter dose showed lower CR for renal arteries.

Conclusions:

  • A Gadobutrol dose of 0.025 mmol/kg BW is justifiable for 7T renal MRA, maintaining diagnostic image quality.
  • This dose reduction is particularly relevant for patients with impaired renal function.
  • Half and full doses yielded the best results, but the reduced dose remains diagnostically adequate.