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Published on: August 11, 2008
Tuberculosis and hypertension-a systematic review of the literature
Anneline Borchsenius Seegert1, Frauke Rudolf2, Christian Wejse2
1Aarhus University, Aarhus, Denmark.
Background:
Tuberculosis (TB) remains a major health problem in low- and middle-income countries, and in many of these countries, the burden of non-communicable diseases such as hypertension is rising. Knowledge about how these diseases influence each other is limited.
Methods:
A systematic review of the literature was performed to evaluate the evidence for an association between hypertension and TB.
Results:
Three retrospective cohort studies, three case-control studies, eight cross-sectional studies, 12 case series, and 20 case reports exploring the association between hypertension and TB were included in the review. One cohort study found a significantly higher prevalence of hypertension among TB patients compared to controls. Cross-sectional studies reported a prevalence of hypertension in TB patients ranging from 0.7% to 38.3%. No studies were designed to assess whether hypertension is a risk factor for developing active TB.
Conclusions:
Overall, no evidence was found to support an association between TB and hypertension; however, the results of this review must be interpreted with caution due to the lack of properly designed studies.
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