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Updated: Mar 9, 2026

Highly Sensitive and Rapid Fluorescence Detection with a Portable FRET Analyzer
Published on: October 1, 2016
A turn-on fluorescence probe for the selective and sensitive detection of fluoride ions
Shan Zhang1,2, Mingtai Sun2, Yehan Yan2
1School of Environment and Chemical Engineering, North China Electric Power University, Beijing, 102206, China.
Abstract:
The sensitive and selective determination of fluoride ions is particularly significant in environmental protection, food safety, and health care products. In this work, a highly selective turn-on fluorescent probe for fluoride ions has been synthesized by simply functionalizing fluorescent isophthalaldehyde with silicone-oxygen bonding. The selectivity of the probe is based on the specific reactivity of the silyl group toward fluoride ions in aqueous solution. The nucleophilic substitution reaction of fluoride ions triggers the cleavage of the Si-O bond to release a strongly fluorescent product, which can be used for the determination of fluoride ions by fluorescence intensity enhancement. The probe molecules are specifically responsive and highly selective for the fluoride anion over other relevant anions and cations. This fluorescent probe also shows high photostability and exhibits good sensitivity for fluoride ions, and the limit of detection is as low as 67 ppb. We have demonstrated its application for on-site sensitive determination of fluoride ions for environmental monitoring and protection.
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