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Related Experiment Video

Updated: Mar 9, 2026

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Published on: May 22, 2019

Podocyte number and density changes during early human life.

Masao Kikuchi^1,2, Larysa Wickman³, Raja Rabah⁴

¹Department of Internal Medicine, Nephrology Division, University of Michigan, 1570B MSRBII, 1150 W Medical Center Drive, Ann Arbor, MI, 48109-0676, USA.

Pediatric Nephrology (Berlin, Germany)

|December 29, 2016

Summary

This summary is machine-generated.

Podocyte number increases early in kidney development, while glomerular volume grows postnatally. This mismatch can impact kidney health and disease manifestation.

Keywords:

Glomerular maturation Glomerular volume Glomerulosclerosis Podocyte Podocyte density

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Area of Science:

Nephrology
Developmental Biology
Pathology

Background:

Podocyte depletion is a key driver of glomerulosclerosis in kidney diseases.
This depletion results from reduced podocyte number, size, or function relative to increasing glomerular volume.

Purpose of the Study:

To analyze podometric parameters during early human kidney development.
To compare developmental changes in podocyte number and glomerular volume.

Main Methods:

Autopsy-obtained kidneys from 24 infants (premature and mature) were analyzed.
Podometric parameters were measured and compared with existing data.

Main Results:

Glomerular volume increased 4.6-fold from fetal stages to maturity.
Podocyte number per glomerulus significantly increased during early development, plateauing by the mature stage.
The primary increase in podocyte number occurs before or during early glomerular development, unlike glomerular volume which continues to grow after birth.

Conclusions:

Podocyte density decreases as glomeruli enlarge postnatally, necessitating increased podocyte size for filtration surface coverage.
Hypertrophic stresses during development and growth may influence the clinical manifestation of podocyte-related genetic disorders.
Therapeutic strategies addressing the mismatch between podocyte number/size and glomerular volume could be beneficial.