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Cortical Alterations in Medication-Overuse Headache.

Franz Riederer1,2, Marie Schaer3,4, Andreas R Gantenbein2,5

  • 1Neurological Center Rosenhuegel and Karl Landsteiner Institute for Epilepsy Research and Cognitive Neurology, Vienna, Austria.

Headache
|December 29, 2016
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Summary
This summary is machine-generated.

Medication-overuse headache (MOH) is linked to neurodevelopmental changes in the brain. Patients with MOH show reduced cortical thickness and altered gyrification, particularly in the prefrontal and occipital regions.

Keywords:
cortical thicknesslocal gyrification indexmedication-overuse headachetreatment response

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Area of Science:

  • Neuroimaging
  • Neurology
  • Brain Morphology

Background:

  • Medication-overuse headache (MOH) involves dysfunctional cortical and subcortical pain modulation.
  • Previous studies reported varied cortical volumes in MOH, but did not distinguish between thickness and gyrification.
  • Differentiating these alterations can clarify neurodevelopmental mechanisms in MOH.

Purpose of the Study:

  • To examine cortical thickness and gyrification in medication-overuse headache (MOH) using surface-based morphometry.
  • To differentiate between changes in cortical thickness and gyrification in MOH patients.
  • To investigate potential neurodevelopmental mechanisms underlying MOH.

Main Methods:

  • Investigated cortical thickness and gyrification in 29 MOH patients and 29 controls.
  • Utilized high-resolution structural MRI scans analyzed with FreeSurfer software.
  • Secondary analysis of data from a prior voxel-based morphometry study.

Main Results:

  • MOH patients exhibited reduced cortical thickness in the left prefrontal cortex compared to controls.
  • Increased local gyrification was observed in the fusiform cortex, medial temporal regions, and right occipital pole.
  • Higher gyrification in the right occipital pole predicted a poorer response to detoxification treatment.

Conclusions:

  • Findings support previous volumetric results and suggest neurodevelopmental alterations in MOH.
  • The study provides insights into the neurobiological mechanisms implicated in medication-overuse headache.
  • Distinguishing cortical thickness and gyrification reveals specific brain changes in MOH.