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[Patho-anatomic changes in rotaviral gastroenteritis in children]
Insights
Two children died from Rotavirus gastroenteritis, confirmed by intestinal tissue analysis. The study details acute enteritis and hepatic fatty infiltration as key indicators of Rotavirus infection in infants.
Area of Science:
- Pediatric infectious diseases
- Gastroenterology
- Virology
Background:
- Rotavirus gastroenteritis is a significant cause of infant mortality globally.
- Understanding the pathological changes associated with severe Rotavirus infection is crucial for diagnosis and treatment.
Observation:
- Two infant deaths were investigated, attributed to Rotavirus gastroenteritis.
- Autopsies revealed characteristic histopathological changes in the small intestine and liver.
Findings:
- Virological, electron microscopic, and immune fluorescence studies confirmed Rotavirus in intestinal tissue.
- Histological examination showed acute diffuse enteritis with villous abnormalities and inflammatory cell infiltration.
- Hepatic tissue exhibited central lobular fatty infiltration, indicative of systemic effects.
Implications:
- These findings underscore the severe pathogenic potential of Rotavirus in infants.
- The detailed pathological description aids in recognizing Rotavirus-induced enteritis.
- Influenza was identified as the cause of pneumonia in one case, highlighting potential co-infections.
Abstract:
Two children (a 6-month-old girl and a 9-month boy) died from Rotavirus gastroenteritis as evidenced by virological, electron microscopic, and immune fluorescence studies of intestinal tissue. Histological and morphometric examinations of the small intestine revealed acute diffuse enteritis with enlarged and shortened villi, infiltration of intrinsic plates with lymphocytes, plasma cells and macrophages, enhanced mitotic activity of epitheliocytes and their increased lymphocyte-induced infiltration. The hepatic tissue showed central lobular fatty infiltration. The above changes should be regarded as manifestations of Rotavirus infection. Pneumonia detected in one of the children had been caused by influenza infection.