Naphthyridines with Antiviral Activity - A Review

Area of Science:

• Medicinal Chemistry
• Pharmacology

Background:

• The naphthyridine scaffold is a key pharmacophore with diverse biological activities, including antiviral properties.
• Naphthyridine analogs exhibit potent antiviral activity, often in the nanomolar range, against various viruses.
• Existing literature lacks a comprehensive review focused specifically on the antiviral applications of naphthyridine derivatives.

Purpose of the Study:

• To systematically review and compile existing literature on the antiviral activities of naphthyridine analogs.
• To consolidate research findings on naphthyridine compounds with demonstrated efficacy against viral infections.

Main Methods:

• Literature search conducted using SciFinder, Google Scholar, and PubMed databases.
• Keywords used included "naphthyridine," "antiviral," "antihiv," and "virus."
• References were filtered to include only those detailing antiviral activities of naphthyridine compounds, excluding in-silico studies, formulation development, and patents.

Main Results:

• A significant number of references were identified through database searches.
• The review focuses exclusively on experimentally validated antiviral activities of naphthyridine compounds.
• Excluded studies related to in-silico analysis, formulation, or patents to maintain focus on direct antiviral effects.

Conclusions:

• This compilation provides a valuable resource for researchers in the field of antiviral drug discovery.
• It will aid in the design and synthesis of novel naphthyridine analogs with enhanced antiviral potency.
• The review underscores the therapeutic potential of naphthyridine derivatives in combating viral diseases.