Influence of sex on hyperfiltration in patients with uncomplicated type 1 diabetes

The aim of this analysis was to examine sex-based differences in renal segmental resistances in healthy controls (HCs) and patients with type 1 diabetes (T1D). We hypothesized that hyperfiltration-an early hemodynamic abnormality associated with diabetic nephropathy-would disproportionately affect women with T1D, thereby attenuating protection against the development of renal complications. Glomerular hemodynamic parameters were evaluated in HC (n = 30) and in normotensive, normoalbuminuric patients with T1D and either baseline normofiltration [n = 36, T1D-N, glomerular filtration rate (GFR) 90-134 ml·min^-1·1.73 m²] or hyperfiltration (n = 32, T1D-H, GFR ≥ 135 ml·min^-1·1.73 m²) during euglycemic conditions (4-6 mmol/l). Gomez's equations were used to derive efferent (R_E) and afferent (R_A) arteriolar resistances, glomerular hydrostatic pressure (P_GLO) from inulin (GFR) and paraaminohippurate [effective renal plasma flow (ERPF)] clearances, plasma protein and estimated ultrafiltration coefficients (K_FG). Female patients with T1D with hyperfiltration (T1D-H) had higher R_E (1,985 ± 487 vs. 1,381 ± 296 dyne·sec^-1·cm^-5, P < 0.001) and filtration fraction (FF, 0.20 ± 0.047 vs. 0.16 ± 0.03 P < 0.05) and lower ERPF (876 ± 245 vs. 1,111 ± 298 134 ml·min^-1·1.73 m²P < 0.05) compared with male T1D-H patients. Overall, T1D-H patients had higher P_GLO and lower R_A vs. HC subjects, although there were no sex-based differences. In conclusion, female T1D-H patients had higher R_E and FF and lower ERPF than their male counterparts with no associated sex differences in R_A Prospective intervention studies should consider sex as a modifier of renal hemodynamic responses to renal protective therapies.