Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Mar 9, 2026

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation.

Sarah De Clercq¹, Marc Keruzore¹, Elodie Desmaris¹

¹ULB Institute of Neuroscience (UNI), Université Libre de Bruxelles (ULB), B-6041 Gosselies, Belgium.

Cerebral Cortex (New York, N.Y. : 1991)

|December 30, 2016

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Emerging role of G-quadruplexes in alternative splicing regulation.

Trends in genetics : TIG·2026

Same author

ENT1 inhibition enhances weight control and metabolic health in diet-induced obesity.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2025

Same author

The Epstein-Barr virus EBNA1 protein binds to G-quadruplexes in its own mRNA hence controlling its expression and immune evasion of the virus.

Nucleic acids research·2025

Same author

Evidence That Dmrta2 Acts through Repression of <i>Pax6</i> in Cortical Patterning and Identification of a Mutation Impairing DNA Recognition Associated with Microcephaly in Human.

eNeuro·2025

Same author

Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex Development and Evidence for Dmrta2 Function in the Choroid Plexus.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025

Same author

Temporal refinement of Dach1 expression contributes to the development of somatosensory neurons.

The EMBO journal·2025

Same journal

A neuroimaging meta-analysis on social impression formation of stable characteristics.

Cerebral cortex (New York, N.Y. : 1991)·2026

Same journal

An expanded cortical map of von Economo neurons in the human medial prefrontal cortex.

Cerebral cortex (New York, N.Y. : 1991)·2026

Same journal

For better and worse: neural self-partner overlap during social feedback is associated with relationship satisfaction and depressive symptoms.

Cerebral cortex (New York, N.Y. : 1991)·2026

Same journal

Regions in the human inferior temporal gyrus are engaged in numerosity processing across visual stimulus categories.

Cerebral cortex (New York, N.Y. : 1991)·2026

Same journal

Differentiation of cortical areas: effects of free energy minimization with broken symmetry.

Cerebral cortex (New York, N.Y. : 1991)·2026

Same journal

Prior exposure to speech rapidly modulates cortical processing of high-level linguistic structure.

Cerebral cortex (New York, N.Y. : 1991)·2026

See all related articles

This summary is machine-generated.

The transcription factor DMRT5 controls neocortical area patterning independently of the cortical hem. Finely tuned DMRT5 and DMRT3 levels are crucial for regulating cerebral cortex development.

Area of Science:

Neuroscience
Developmental Biology
Genetics

Background:

The cerebral cortex exhibits complex patterning, with specific regions like the cortical hem acting as crucial signaling centers.
The role of specific transcription factors in directing neocortical area map formation remains an active area of research.

Purpose of the Study:

To investigate the function of the Dmrt5 gene in neocortical patterning.
To determine if Dmrt5 acts independently of the cortical hem in regulating the neocortical area map.
To elucidate the relationship between Dmrt5 and Dmrt3 in cortical development.

Main Methods:

Utilized conditional Dmrt5 gain and loss of function mouse models.
Analyzed changes in neocortical area maps and cortical patterning.

Keywords:

cortical hem hippocampus neocortex neocortical area map transcription factor

More Related Videos

Dissection of Hippocampal Dentate Gyrus from Adult Mouse

Dissection of Hippocampal Dentate Gyrus from Adult Mouse

Published on: November 17, 2009

Ex Utero Electroporation and Organotypic Slice Culture of Mouse Hippocampal Tissue

Ex Utero Electroporation and Organotypic Slice Culture of Mouse Hippocampal Tissue

Published on: March 4, 2015

Related Experiment Videos

Last Updated: Mar 9, 2026

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

Dissection of Hippocampal Dentate Gyrus from Adult Mouse

Dissection of Hippocampal Dentate Gyrus from Adult Mouse

Published on: November 17, 2009

Ex Utero Electroporation and Organotypic Slice Culture of Mouse Hippocampal Tissue

Ex Utero Electroporation and Organotypic Slice Culture of Mouse Hippocampal Tissue

Published on: March 4, 2015

Examined Dmrt5 and Dmrt3 expression patterns and regulatory interactions.

Main Results:

Constitutive Dmrt5 null mice displayed cortical patterning abnormalities, including loss of the cortical hem.
Conditional Dmrt5 manipulation altered the neocortical area map without affecting the hem, indicating DMRT5's independent role.
Dmrt5 deletion impacted hippocampal size and the neocortical/paleocortical boundary.
Dmrt3 deficiency caused milder patterning defects, with Dmrt5 expression increasing in its absence.
DMRT5 upregulates Dmrt3 and negatively autoregulates itself, stabilizing DMRT5 levels.

Conclusions:

DMRT5 is a key transcription factor directing the rostral-to-caudal pattern of the neocortical area map, independent of the cortical hem.
DMRT5 and DMRT3 act in concert, with precisely regulated levels, to control cerebral cortex patterning.
These findings identify DMRT5 as a critical regulator of neocortical area size and position.