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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

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Elevated Factor VIII Levels Associated with Acute Graft Occlusion and Arterial and Venous Thrombosis After Off Pump

Crystal A Kyaw1, Pey-Jen Yu1, Frank Manetta1

  • 1Department of Cardiovascular and Thoracic Surgery, Hofstra North Shore-Long Island Jewish School of Medicine, Manhasset, New York.

The International Journal of Angiology : Official Publication of the International College of Angiology, Inc
|December 30, 2016
PubMed

Factor VIII is a common acute phase reactant and elevated levels confer an increased risk of thrombosis. Such thrombotic events have been documented in the literature, though to a limited extent. We present the case of a 54-year-old man presenting with a non-Q-wave myocardial infarction who was found to have triple vessel disease and subsequently underwent a 4-vessel coronary artery bypass grafting (CABG). Postoperatively, he was found to have multiple occluded vessels, deep vein thromboses, and a cerebrovascular accident (CVA). A hypercoagulability work-up revealed significantly elevated levels of factor VIII at 377% normal, which likely contributed to these thrombotic events. Further exploration is warranted to elucidate causal mechanisms of these thrombotic events, particularly of multiple graft occlusions, and to guide clinical decision making with regards to anticoagulation and stent management.

Keywords:
acute arterial thrombosiscoronary artery diseasefactor VIIIpost-CABG thrombosis

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