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Related Experiment Video

Updated: Mar 9, 2026

Generation of Self-assembled Vascularized Human Skin Equivalents

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Published on: February 12, 2021

Neonatal Soft Tissue Reconstruction Using a Bioengineered Skin Substitute.

Scott D Hirsch¹, Jeremy M Powers, Jennifer L Rhodes

¹Division of Plastic and Reconstructive Surgery, Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA.

The Journal of Craniofacial Surgery

|December 30, 2016

Summary

This summary is machine-generated.

Total parenteral nutrition (TPN) in premature neonates can cause tissue damage. A newborn treated with Apligraf showed rapid healing of a severe TPN extravasation injury, highlighting a novel treatment approach.

Area of Science:

Neonatal care
Regenerative medicine
Pediatric surgery

Background:

Total parenteral nutrition (TPN) is crucial for premature neonates but peripheral administration carries risks.

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Extravasation injuries from TPN can lead to significant tissue damage in neonates.

Limited evidence exists for treating these injuries in this vulnerable population.