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Updated: Mar 9, 2026

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
Published on: August 31, 2022
Skeletal Scintigraphy in Radiation-Induced Fibrosis With Lymphedema
Jieqi Wang1, Arya M Iranmanesh, M Elizabeth Oates
1From the *University of Kentucky College of Medicine; †Department of Radiology, University of Kentucky College of Medicine; and ‡Division of Nuclear Medicine & Molecular Imaging, Department of Radiology, University of Kentucky College of Medicine, Lexington, KY.
Abstract:
Despite increasing reliance on CT, MRI, and FDG PET/CT for oncological imaging, whole-body skeletal scintigraphy remains a frontline modality for staging and surveillance of osseous metastatic disease. We present a 54-year-old woman with metastatic breast cancer who received palliative external-beam radiation to the left ilium. Serial follow-up Tc-MDP bone scans demonstrated progressive soft-tissue uptake in her left lower extremity, extending from thigh to leg, with associated enlargement and skin thickening, consistent with lymphedema related to radiation-induced fibrosis. Correlative abdominopelvic CT scans confirmed fibrotic changes in the left thigh.
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