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Membrane assisted and temperature controlled on-line evaporative concentration for microfluidics.
E Fornells1, B Barnett2, M Bailey3
1ASTech, ARC Training Centre for Portable Analytical Separation Technologies, Australia; Australian Centre for Research on Separation Science, School of Physical Sciences, University of Tasmania, Private Bag 75, Hobart, Tasmania 7001, Australia.
Journal of Chromatography. A
|December 31, 2016
Summary
A novel membrane evaporation concentrator achieves 30-fold concentration in under an hour for continuous flow systems. Precise temperature control enables efficient analyte concentration for various analytical methods.
Area of Science:
- Analytical Chemistry
- Chemical Engineering
Background:
- Traditional sample concentration methods can be time-consuming and may compromise analyte integrity.
- Continuous flow systems require efficient and rapid sample processing techniques.
Purpose of the Study:
- To introduce and evaluate a membrane evaporation concentrator for continuous flow conditions.
- To develop a theoretical model for predicting concentrator performance.
- To demonstrate the ability to achieve significant concentration factors while preserving solute integrity.
Main Methods:
- Development of a membrane evaporation concentrator for continuous sample processing.
- Utilizing caffeine as a model analyte to validate the theoretical model.
- Predicting concentration performance for target analytes under varying conditions.
- Investigating the relationship between temperature and concentration factor.
Main Results:
- Achieved nearly 30-fold concentration in under 60 minutes.
- Demonstrated solute integrity maintenance under sub-ambient pressure and mild temperatures.
- Established an exponential relationship between temperature and concentration factor.
- Predicted a 10-fold concentration at 56.72°C and 10 μL/min flow rate.
Conclusions:
- The developed model enhances understanding and application of the membrane evaporation concentrator.
- Precise temperature control is crucial for efficient concentration in continuous flow systems.
- This method offers a viable alternative to existing evaporation concentration procedures for analytical applications.
