Related Experiment Video
Updated: Mar 9, 2026

Author Spotlight: Advancements in 3D Optical Imaging for Comprehensive Body Composition Assessment in Modern Research
Published on: June 7, 2024
Bone Variables in Active Overweight/Obese Men and Sedentary Overweight/Obese Men
Georges El Khoury1, Hassane Zouhal2, Geneviève Cabagno3
1Department of Physical Education, Faculty of Arts and Social Sciences, University of Balamand, El-Koura, Lebanon; Laboratoire VIP'S, UFR-APS, Campus la Harpe, Université Rennes 2, Rennes, France.
Physical activity significantly improves bone health in overweight and obese men. Active men show better bone mineral content, density, and hip strength compared to sedentary men, suggesting exercise can prevent osteoporosis.
Area of Science:
- Exercise Physiology
- Bone Metabolism
- Obesity Research
Background:
- Overweight and obesity are associated with altered bone metabolism.
- The impact of physical activity on bone health in this population requires further investigation.
Purpose of the Study:
- To compare bone variables between active and sedentary overweight/obese men.
- To explore the relationship between physical fitness, lean mass, muscle strength, and bone health in overweight/obese men.
Main Methods:
- DXA scans measured body composition and bone variables (BMC, BMD, hip bone strength indices).
- Validated questionnaires assessed physical activity, calcium/protein intake, and sleep.
- Cardiorespiratory fitness (VO2 max) and lower limb muscular strength (half-squat 1RM) were directly measured.
Main Results:
- Sedentary overweight/obese men had higher body weight and BMI than active men.
- VO2 max, lean mass, and half-squat strength positively correlated with bone mineral content, density, and hip strength.
- Active overweight/obese men exhibited superior whole-body BMC, lumbar spine BMD, total hip BMD, and femoral neck strength indices.
Conclusions:
- Physical activity level is a key determinant of bone health in overweight and obese men.
- Maintaining lean mass and muscular strength through exercise may help prevent osteoporosis in this demographic.
Related Concept Videos
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Drug Dosing: Obese Patients
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Obesity
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

