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Updated: Mar 9, 2026

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
Published on: January 7, 2019
Occupational HIV Infection in a Research Laboratory With Unknown Mode of Transmission: A Case Report
Alessandro Soria1, Claudia Alteri2, Gabriella Scarlatti3
1Division of Infectious Diseases, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
Abstract:
A laboratory worker was infected with human immunodeficiency virus (HIV) type 1 in a biosafety level 2 containment facility, without any apparent breach. Through full-genome sequencing and phylogenetic analyses, we could identify the source of infection in a replication-competent clone that unknowingly contaminated a safe experiment. Mode of transmission remains unclear. Caution is warranted when handling HIV-derived constructs.
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