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Pathogenesis of Fungal Infections in Cystic Fibrosis

Craig Williams1, Ranjith Ranjendran2, Gordon Ramage2

  • 1Institute of Healthcare Policy and Practice, University of West of Scotland, Paisley, UK.

Current Fungal Infection Reports
|December 31, 2016
PubMed

Insights

Fungi, including moulds and yeasts, are increasingly recognized in cystic fibrosis (CF) lung infections. While their exact role is unclear, evidence suggests fungi contribute to CF pathogenesis alongside bacteria.

Area of Science:

  • Medical Microbiology
  • Pulmonary Medicine
  • Mycology

Background:

  • Cystic Fibrosis (CF) microbiology research has historically focused on bacterial pathogens like *Pseudomonas aeruginosa*.
  • Emerging evidence highlights the presence and potential significance of fungal organisms (moulds and yeasts) in the CF respiratory tract.
  • The precise ecological and pathogenic role of these fungi in CF remains incompletely understood.

Approach:

  • This review synthesizes current research on the involvement of fungi in cystic fibrosis.
  • It examines evidence supporting the contribution of fungi to the complex disease process.
  • The review discusses the potential direct or indirect pathogenic mechanisms of fungal co-infections.

Key Points:

  • Fungi are frequently detected in the airways of individuals with cystic fibrosis.
  • The clinical significance of fungal presence, whether pathogenic or commensal, is under active investigation.
  • Understanding fungal roles is crucial for comprehensive CF management.

Conclusions:

  • Fungi represent a significant component of the cystic fibrosis airway microbiome.
  • Further research is crucial to elucidate the direct or indirect pathogenic roles of fungi in CF.
  • Understanding fungal involvement may lead to improved therapeutic strategies for cystic fibrosis patients.
Keywords:
Cystic fibrosisFungal infectionsPathogenesisPseudomonas aeruginosaReview

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