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Updated: Mar 9, 2026
06:47
Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
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Osteogenic Differentiation in Healthy and Pathological Conditions
Maria Teresa Valenti1, Luca Dalle Carbonare2, Monica Mottes3
1Department of Medicine, Section of Internal Medicine D, University of Verona, 37128 Verona, Italy. mariateresa.valenti@univr.it.
International Journal of Molecular Sciences
|December 31, 2016
Summary
This review explores how mesenchymal stem cells (MSCs) differentiate for bone formation. It details molecular pathways in healthy and diseased states, including aging and osteoporosis, impacting bone repair.
Area of Science:
- Biomedical Science
- Cell Biology
- Skeletal Biology
Background:
- Mesenchymal stem cells (MSCs) are crucial for bone formation and remodeling.
- Bone remodeling is a lifelong process regulated by complex molecular pathways.
- Dysregulation of these pathways leads to skeletal disorders.
Purpose of the Study:
- To review the osteogenic differentiation of MSCs and its role in bone formation.
- To describe molecular pathways controlling bone remodeling in physiological and pathological conditions.
- To discuss the implications of abnormal MSC differentiation in aging, osteoporosis, genetic disorders, and cancer, and potential clinical applications.
Main Methods:
- Literature review of molecular pathways involved in osteogenesis.
- Analysis of MSC differentiation in various skeletal conditions.
- Discussion of genetic mutations affecting bone development.
- Overview of MSC-based bone regeneration strategies.
Main Results:
- Aging and glucocorticoid-induced osteoporosis involve impaired MSC osteogenic commitment favoring adipogenesis.
- Mutations in key bone development genes cause heritable bone disorders.
- Abnormal MSC differentiation is implicated in cancer.
- MSCs show potential for bone regeneration and repair.
Conclusions:
- MSC osteogenic differentiation is central to skeletal health and disease.
- Understanding these pathways is key to addressing bone loss and disorders.
- MSC-based therapies offer promising avenues for bone regeneration.
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