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Updated: Mar 9, 2026

Fabrication of an Expandable Brain Matrix Customizable Across Developmental Stages
Published on: February 20, 2026
Tooth-Matrix Biomarkers to Reconstruct Critical Periods of Brain Plasticity
Hirofumi Morishita1, Manish Arora2
1Department of Psychiatry, Neuroscience, and Ophthalmology, Friedman Brain Institute, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Abstract:
Developmental brain plasticity involves complex, time-dependent dynamic molecular interactions that cannot be observed directly in humans. We propose that the shared evolutionary homology of teeth and the neurosensory system, and the archival nature of dentine microstructure, allows the development of 'biologic hard drives' that can characterize perinatal temporal dynamics in neuroplasticity.
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