Related Experiment Video
Updated: Mar 9, 2026
09:58
Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
4.1K
Recent advances in lipidomics: Analytical and clinical perspectives
1Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil.
Prostaglandins & Other Lipid Mediators
|January 1, 2017
Summary
Lipidomics, the study of lipids, offers insights into health and disease. Advances in technology enhance lipid analysis for discovering biomarkers and understanding disease mechanisms.
Area of Science:
- Biochemistry
- Metabolomics
- Lipidomics
Background:
- Lipidomics is a lipid-targeted metabolomics approach for comprehensive lipid analysis.
- Challenges in lipidomics stem from lipid complexity and analytical tool limitations.
- Genomic and proteomic fields currently offer more extensive information than lipidomics.
Purpose of the Study:
- To review advances in lipidomics technologies.
- To highlight applications in disease biomarker discovery and clinical practice.
- To discuss future perspectives and challenges in lipidomics.
Main Methods:
- Technological advancements in mass spectrometry.
- Developments in chromatography for lipid analysis.
- Metabolic profiling of diverse lipids in biological samples.
Main Results:
- Improved capabilities for analyzing diverse lipids in complex biological samples.
- Identification of potential biomarkers for disease prevention and therapy.
- New insights into lipid profiling and pathophysiological mechanisms in clinical studies.
Conclusions:
- Lipidomics provides crucial insights into lipid functions in health and disease.
- Technological progress is driving the application of lipidomics in clinical studies.
- Further development is needed to address challenges and realize the full potential of lipidomics.
Related Concept Videos
01:24Overview of Lipid Metabolism
6.3K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
6.3K
01:31Lipid-derived Compounds in the Human Body
7.2K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
7.2K
01:24Lipid Absorption
3.2K
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
3.2K
01:06Lipid Digestion
101.4K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
101.4K
01:29Pharmacogenomics: Identification of New Drug Targets
57
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
57
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
726
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
726