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Obstructive sleep and atrial fibrillation: Pathophysiological mechanisms and therapeutic implications
Christos A Goudis1, Dimitrios G Ketikoglou2
1Cardiology Department, Serres General Hospital, Serres, Greece.
International Journal of Cardiology
|January 2, 2017
Summary
Obstructive sleep apnea (OSA) is a significant risk factor for atrial fibrillation (AF). Continuous positive airway pressure (CPAP) therapy can reduce AF recurrence by addressing OSA-related mechanisms.
Area of Science:
- Cardiology
- Sleep Medicine
- Internal Medicine
Background:
- Atrial fibrillation (AF) is a prevalent arrhythmia linked to increased cardiovascular risks.
- Obstructive sleep apnea (OSA) is an independent risk factor for AF development and recurrence.
Purpose of the Study:
- To review the relationship between OSA and AF.
- To explore pathophysiological mechanisms linking OSA to AF.
- To update on therapeutic interventions for comorbid OSA and AF.
Main Methods:
- Literature review of studies investigating OSA and AF.
- Analysis of pathophysiological pathways involved in AF occurrence in OSA patients.
- Evaluation of therapeutic strategies, including CPAP, for OSA and AF management.
Main Results:
- OSA contributes to AF through hypoxia, pressure shifts, inflammation, and oxidative stress.
- OSA negatively impacts the efficacy of AF treatments like drugs, cardioversion, and ablation.
- CPAP therapy mitigates OSA-related sympathovagal activation and reduces AF recurrence.
Conclusions:
- OSA is a critical factor in AF etiology and management.
- Understanding OSA's mechanisms in AF is crucial for effective treatment.
- CPAP represents a key therapeutic intervention for patients with both OSA and AF.
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