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Targeting fibroblast growth factor pathways in endometrial cancer

Boris Winterhoff1, Gottfried E Konecny2

  • 1Department of Obstetrics and Gynecology, University of Minnesota, Minneapolis, Minnesota.

Current Problems in Cancer
|January 3, 2017
PubMed

Insights

Novel treatments are needed for recurrent or metastatic endometrial cancer (EC). Fibroblast growth factor receptor (FGFR) mutations in EC present a target for new therapies, with several FGFR-targeted drugs in development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Endometrial cancer (EC) with recurrence or metastasis lacks effective treatments.
  • Fibroblast growth factor (FGF) and FGF receptor (FGFR) signaling is crucial in various cancers.
  • Activating FGFR2 mutations occur in up to 16% of endometrial cancers.

Purpose of the Study:

  • To review the role of the FGF pathway in angiogenesis and EC.
  • To provide an overview of FGFR-targeted therapies for EC.

Main Methods:

  • Literature review of the FGF pathway in EC.
  • Summary of clinical development of FGFR-targeted therapies.

Main Results:

  • The FGF pathway plays a significant role in angiogenesis and EC progression.
  • FGFR-targeted therapies show promise for EC treatment.

Conclusions:

  • Targeting FGFR2 mutations is a viable therapeutic strategy for EC.
  • FGFR-targeted therapies are advancing in clinical development for EC.
Keywords:
AngiogenesisEndometrial cancerFibroblast growth factor

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