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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
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Symptom Burden in Advanced Soft-Tissue Sarcoma.

Nicholas Gough1, Jonathan Koffman2, Joy R Ross3

  • 1Royal Marsden and Royal Brompton Palliative Care Service, Royal Marsden NHS Foundation Trust, London, UK; The Institute of Cancer Research, London, UK.

Journal of Pain and Symptom Management
|January 3, 2017
PubMed
Summary
This summary is machine-generated.

Patients with advanced soft-tissue sarcoma (STS) experience a significant symptom burden, comparable to other cancers. Early screening and intervention for common symptoms like pain and fatigue are crucial, alongside timely palliative care (PC) referrals.

Keywords:
Advanced soft-tissue sarcomacancerpalliative careprevalence study

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Area of Science:

  • Oncology
  • Palliative Care
  • Symptom Management

Background:

  • Limited data exists on symptom prevalence and severity in advanced soft-tissue sarcoma (STS).
  • Understanding the symptom burden is vital for optimizing clinical consultations and supportive care referrals.
  • Symptom burden significantly impacts patient quality of life and treatment adherence.

Purpose of the Study:

  • To quantify and compare symptom prevalence and severity across different treatment modalities in advanced STS patients.
  • To evaluate symptom burden in patients receiving first-line palliative chemotherapy (FLC), active surveillance (AS) pre- and post-FLC, and palliative care (PC) alone.
  • To inform clinical practice regarding symptom management and timing of PC referrals.

Main Methods:

  • A cross-sectional survey was conducted at a single sarcoma center.
  • The Memorial Symptom Assessment Scale-Short Form (MSAS-SF) was used for patient-reported symptom assessment.
  • Symptom prevalence, severity, and MSAS-SF subscale scores were recorded before initiating new treatments.

Main Results:

  • 113 advanced STS patients were recruited, with varying treatment allocations.
  • The median number of reported symptoms was 11, with symptom burden increasing from AS pre-FLC to PC alone.
  • Common symptoms included pain (77%), lack of energy (73%), and difficulty sleeping (56%). Psychological distress was moderate but higher than in comparative cancer data.

Conclusions:

  • Advanced STS patients face a substantial symptom burden, comparable to other cancer types.
  • Routine screening for prevalent symptoms such as pain, fatigue, and sleep disturbances is recommended.
  • Timely integration of palliative care services is essential for managing symptom burden in advanced STS.