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Related Experiment Video

Updated: Mar 9, 2026

Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors
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Improved Tumor Uptake by Optimizing Liposome Based RES Blockade Strategy.

Xiaolian Sun1, Xuefeng Yan2, Orit Jacobson2

  • 1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, Maryland 20892, United States.

Theranostics
|January 3, 2017
PubMed
Summary
This summary is machine-generated.

Pretreating with liposomes significantly reduces nanomaterial clearance by the reticuloendothelial system (RES), prolonging circulation and enhancing tumor accumulation for improved cancer therapy.

Keywords:
Enhanced tumor uptake.Liposome blockadeNanoparticlePositron Emission TomographyReticuloendothelial system

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Radiopharmacology

Background:

  • Minimizing reticuloendothelial system (RES) sequestration enhances nanomaterial (NM) circulation time and tumor accumulation.
  • Liposomes are generally regarded as safe (GRAS) agents that can temporarily block the RES.

Purpose of the Study:

  • To evaluate the effectiveness of liposome pretreatment in reducing RES sequestration of gold nanorods (Au NRs).
  • To optimize liposome characteristics (charge, dose, timing) for enhanced NM delivery.
  • To assess the impact of liposomes on Au NR biodistribution and tumor uptake using PET imaging.

Main Methods:

  • Positron emission tomography (PET) was used to monitor the in vivo distribution of 64Cu-labeled gold nanorods (Au NRs).
  • Mice were pretreated with varying doses and charges of liposomes at different time intervals before Au NR administration.
  • Liver, spleen, and tumor uptakes of Au NRs were quantified and compared between control and pretreated groups.

Main Results:

  • Pre-injecting 400 μmol/kg of positively charged liposomes 5 hours before Au NRs decreased liver and spleen uptake by 30% and 53%, respectively.
  • U87MG tumor uptake of Au NRs increased from 11.5 ± 1.1 %ID/g to 16.1 ± 1.3 %ID/g at 27 hours post-injection.
  • Liposome pretreatment significantly reduced RES clearance and prolonged NM circulation time.

Conclusions:

  • Quantitative PET imaging is valuable for understanding NM biodistribution in vivo.
  • Cationic liposomal pretreatment is a viable strategy to reduce RES clearance of NMs.
  • This approach effectively prolongs circulation and improves tumor uptake of nanomaterials for potential therapeutic applications.