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Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
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Immune Checkpoints Aberrations and Malignant Mesothelioma: Assessment of Prognostic Value and Evaluation of

Hadeer Mohamed1, Mostafa Eltobgy1, Omar Abdel-Rahman2

  • 1Faculty of Medicine, Ain Shams University, Cairo. Egypt.

Anti-Cancer Agents in Medicinal Chemistry
|January 3, 2017
PubMed

Insights

Malignant pleural mesothelioma (MPM) is difficult to treat. This review covers immune checkpoint aberrations and novel therapies for MPM management.

Area of Science:

  • Oncology
  • Immunology
  • Thoracic Surgery

Background:

  • Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer.
  • Current treatments for MPM have limited efficacy.
  • Immune checkpoint inhibitors (ICIs) show promise in various cancers.

Purpose of the Study:

  • To review the prognostic significance of immune checkpoint aberrations in MPM.
  • To discuss novel therapeutic strategies utilizing ICIs for MPM management.

Main Methods:

  • Comprehensive literature review of studies on MPM and immune checkpoints.
  • Analysis of prognostic markers related to immune checkpoint expression.
  • Evaluation of clinical trial data for ICI efficacy in MPM.

Main Results:

  • Aberrations in immune checkpoints like PD-1/PD-L1 and CTLA-4 are common in MPM.
  • These aberrations correlate with tumor progression and patient prognosis.
  • Emerging data suggests significant clinical benefit from ICI therapy in MPM patients.

Conclusions:

  • Immune checkpoint aberrations are critical in MPM pathogenesis and prognosis.
  • ICIs represent a promising therapeutic avenue for malignant pleural mesothelioma.
  • Further research is needed to optimize ICI strategies for improved MPM outcomes.
Keywords:
Mesotheliomaimmuneipilimumabpembrolizumabprognostic value.tremelimumab

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