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Updated: Mar 9, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
Remote controlled drug release from multi-functional Fe3O4/GO/Chitosan microspheres fabricated by an electrospray
Sheng Li1, Ling Xiao1, Hongbing Deng1
1School of Resource and Environmental Science, Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430072, PR China.
Abstract:
The construction of multifunctional microspheres for remote controlled drug release requires the exquisite selection of composite materials and preparation approaches. In this study, chitosan, an amino polysaccharide, was blended with inorganic nanocomponents, Fe3O4 and graphene oxide (GO) and electrosprayed to fabricate uniform microspheres with the diameters ranging from 100μm to 1100μm. An anti-cancer drug, doxorubicin (DOX), was loaded to the microspheres by an adsorption or embedding method. The microsphere is responsive to magnetic fields due to the presence of Fe3O4, and the incorporation of GO enhanced the drug loading capacity. The fast stimuli-responsive release of DOX can be facilely controlled by using NIR irradiation due to the strong photo-thermal conversion of Fe3O4 and GO. In addition, ultrasound was used as another external stimulus for DOX release. The results suggest the Fe3O4/GO/Chitosan microspheres fabricated by the electrospray method provide an efficient platform for remote controlled drug release, which may have potential applications in drug eluting microspheres.
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