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Nanomaterials for In Vivo Imaging.

Bryan Ronain Smith1, Sanjiv Sam Gambhir2

  • 1Stanford University , 3155 Porter Drive, #1214, Palo Alto, California 94304-5483, United States.

Chemical Reviews
|January 4, 2017
PubMed
Summary

Nanomaterials are revolutionizing in vivo imaging for diagnostics and research by providing high-resolution contrast. Their magnetic, optical, acoustic, and nuclear properties are key for clinical translation.

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Area of Science:

  • Medical Imaging
  • Nanotechnology
  • Materials Science

Background:

  • In vivo imaging is crucial for clinical diagnostics and research.
  • High-resolution, high-contrast imaging requires advanced contrast agents.
  • Nanomaterials offer enhanced capabilities for various imaging modalities.

Purpose of the Study:

  • To review nanomaterials for in vivo imaging.
  • To categorize nanomaterials based on their physical properties (magnetic, optical, acoustic, nuclear).
  • To evaluate nanomaterials for clinical translation potential.

Main Methods:

  • Stratification of nanomaterials by physical properties (magnetic, optical, acoustic, nuclear).
  • Evaluation of nanomaterials for preclinical and clinical utility.
  • Assessment of in vivo safety profiles and modularity for multimodal applications.

Main Results:

  • Nanomaterials are essential for signal generation in many imaging modalities.
  • They offer improved sensitivity, multiplexing, and design modularity.
  • In vivo safety and multimodal capabilities are critical for clinical translation.

Conclusions:

  • Nanomaterials are pivotal for advancing in vivo imaging and precision diagnostics.
  • Their physicochemical design, based on physical properties, dictates imaging performance.
  • Clinical translation hinges on safety, efficacy, and multimodal potential.