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Related Experiment Videos

Osteocalcin levels in diabetic subjects.

M Pedrazzoni1, G Ciotti, G Pioli

  • 1Institute of Clinica Medica Generale E Terapia Medica, University of Parma, Italy.

Calcified Tissue International
|December 1, 1989
PubMed
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Diabetes mellitus is linked to lower bone turnover, particularly in non-insulin-dependent diabetes. Osteocalcin levels were reduced, correlating with parathyroid hormone and calcitonin, suggesting complex bone metabolism changes in diabetic patients.

Area of Science:

  • Endocrinology
  • Metabolic Bone Disease

Background:

  • Diabetes mellitus is associated with potential alterations in bone and mineral metabolism.
  • Previous reports suggest a link between diabetes and abnormal bone turnover.

Purpose of the Study:

  • To investigate differences in bone turnover, specifically serum osteocalcin (OC) levels, in diabetic patients compared to normal controls.
  • To explore the relationship between OC levels and other mineral metabolism markers (calcium, calcitonin, parathyroid hormone) in diabetes.

Main Methods:

  • Studied 106 diabetic subjects (42 insulin-dependent diabetes mellitus [IDD] and 64 non-insulin-dependent diabetes mellitus [NIDD]).
  • Evaluated bone turnover using serum osteocalcin (OC) levels.
  • Measured serum calcium (Ca), calcitonin (CT), and parathyroid hormone (PTH).

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  • Utilized multiple regression analysis to identify factors influencing OC levels.

    • Main Results:

    • Diabetic subjects exhibited lower serum osteocalcin (OC) levels than predicted values.
    • The reduction in OC was most pronounced in non-insulin-dependent diabetes mellitus (NIDD) patients.
    • Serum calcium (Ca) and calcitonin (CT) levels were generally higher in diabetic subgroups, while parathyroid hormone (PTH) was lower.
    • Diet-controlled subjects showed a greater reduction in OC compared to those treated with oral hypoglycemic agents or insulin.

    Conclusions:

    • Diabetes mellitus is associated with significantly reduced bone turnover, indicated by lower osteocalcin levels.
    • Bone metabolism in diabetes is complex, influenced by parathyroid hormone, calcitonin, and treatment type, with other factors likely playing a role.