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Bisphenol A interferes with swine vascular endothelial cell functions
Giuseppina Basini1,1, Simona Bussolati1,1, Stefano Grolli1,1
1Dipartimento di Scienze Medico-Veterinarie, Università degli Studi di Parma, Via del Taglio 10, 43126 Parma, Italy.
Canadian Journal of Physiology and Pharmacology
|January 5, 2017
Summary
Bisphenol A (BPA), an endocrine disruptor, promotes vascular growth by stimulating endothelial cell growth and vascular endothelial growth factor (VEGF) production. This may lead to uncontrolled neovascularization and associated health risks.
Area of Science:
- Endocrinology
- Vascular Biology
- Toxicology
Background:
- Endocrine disruptors like bisphenol A (BPA) are known to negatively impact health.
- The role of BPA in disrupting angiogenesis, the formation of new blood vessels, is suspected but not fully understood.
- Vascular endothelial growth factor (VEGF) and nitric oxide (NO) are critical regulators of angiogenesis.
Purpose of the Study:
- To investigate the effects of BPA on the angiogenic process.
- To determine how BPA influences the production of VEGF and NO in endothelial cells.
- To clarify the mechanisms by which BPA may interfere with vascular homeostasis.
Main Methods:
- Utilized a validated three-dimensional in vitro angiogenesis assay with an immortalized swine aortic endothelial cell line (AOC).
- Evaluated the impact of BPA (10 μmol/L) on AOC growth and new blood vessel development.
- Measured the production of VEGF and NO by AOC cells following BPA exposure.
Main Results:
- BPA significantly stimulated AOC growth (p < 0.05).
- BPA exposure led to increased VEGF production by AOC cells (p < 0.05).
- BPA did not significantly alter NO levels in AOC cells.
Conclusions:
- BPA's endocrine-disrupting properties extend to promoting vascular growth.
- The stimulation of VEGF by BPA may disrupt the delicate balance of angiogenesis, potentially favoring uncontrolled neovascularization.
- Increased understanding of BPA's effects on angiogenesis is crucial for monitoring potential health risks, particularly in pathologies involving abnormal blood vessel formation, such as cancer.
