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Altered tolbutamide pharmacokinetics by a decrease in hepatic expression of CYP2C6/11 in rats pretreated with

Shuhei Fukuno1, Katsuhito Nagai1,2, Keita Kasahara1

  • 1a Laboratory of Clinical Pharmacy and Therapeutics , Faculty of Pharmacy, Osaka Ohtani University , Tondabayashi , Japan and.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
|January 5, 2017
PubMed
Summary

Single 5-fluorouracil (5-FU) administration altered tolbutamide (TB) pharmacokinetics in rats. This change was linked to reduced CYP2C6/11 gene expression and metabolic activity, impacting drug clearance.

Keywords:
5-fluorouracilCYP2Cmetabolic eliminationpharmacokineticsrattolbutamide

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