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Related Concept Videos

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Advances in Psoriasis.

Jaclyn Smith1, Abigail Cline1, Steven R Feldman1

  • 1From the Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Southern Medical Journal
|January 5, 2017
PubMed
Summary
This summary is machine-generated.

Psoriasis treatments, from topicals to biologics, are advancing for better symptom control and fewer side effects. Coordinated care and new therapies promise improved patient outcomes and satisfaction.

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Psoriasis management involves diverse treatments, including topicals, phototherapy, oral medications, and injections.
  • Current treatments offer good disease control but advancements are needed for improved outcomes.

Purpose of the Study:

  • To review traditional and novel psoriasis treatments.
  • To guide clinical application of these therapies.

Main Methods:

  • A literature review was conducted using PubMed.
  • Focus on psoriasis treatments and clinical applications.

Main Results:

  • Mild-to-moderate psoriasis: topicals, localized phototherapy, combination therapies, and novel vehicles (foams, sprays).
  • Moderate-to-severe psoriasis: generalized phototherapy, oral agents, biologics, with new oral and biologic agents emerging.
  • Screening for comorbidities (cardiovascular, metabolic, autoimmune) is crucial.

Conclusions:

  • Continued advancements in psoriasis treatment and coordinated care are essential.
  • Improved therapies and integrated management will enhance patient care and satisfaction.